Cytoplasmic Dynein Complex: A Promising Drug Target and Biomarker

Target Name: Cytoplasmic dynein complex

NCBI ID: P28233

Cytoplasmic dynein complex

Other Name(s): cytoplasmic dynein intermediate light chain | cytoplasmic dynein intermediate chain | cytoplasmic dynein light chain | cytoplasmic dynein heavy chain

Cytoplasmic Dynein Complex: A Promising Drug Target and Biomarker

Cytoplasmic dynein complex (CDC) is a protein complex that plays a critical role in the cytoskeleton organization and mechanical functions of eukaryotic cells. It is composed of the protein dynein, which is essential for the proper functioning of mitochondria, and other non-protein components, including the nucleotide GDP, F1ATP, and several nucleic acids. CDC is involved in a wide range of cellular processes, including cell division, mitochondrial fusion, and cytoskeleton organization.

The identification of CDC as a potential drug target and biomarker has significant implications for the development of new therapeutic strategies for various diseases, including cancer, neurodegenerative disorders, and cardiovascular diseases. In this article, we will explore the current state of research on CDC and its potential as a drug target and biomarker.

CDP and CDC Complexity

CDP (cytoplasmic dynein protein) and CDC (cytoplasmic dynein complex) are closely related proteins that share a common ancestor. CDP is a 12-kDa protein that is essential for the proper functioning of mitochondria, while CDC is a protein complex composed of several non-protein components that functions to regulate the cytoskeleton organization and mechanical functions of eukaryotic cells.

The N-end of CDP contains a domain that is similar to that of the kappa subunit of the ATPase, while the C-end contains a domain that is similar to that of the beta subunit. This suggests that CDP and CDC may share a common ancestor that developed through a process of gene duplication and subsequent evolution.

Function and regulation

CDP is involved in the proper functioning of mitochondria, which are critical for the production of energy by the cell through the process of cellular respiration. CDP functions as a cofactor for the mitochondrial F1F0 ATPase, which is responsible for generating ATP through a process that involves a high-energy transition.

CDP is also involved in the regulation of cytoskeleton organization and mechanical functions. It interacts with several microtubule proteins, including tubulin, to form the cytoskeleton and maintain the integrity of the cytoskeleton during cell division and mechanical processes.

CDC is a protein complex that is involved in the regulation of various cellular processes, including cell division, mitochondrial fusion, and cytoskeleton organization. It is composed of several non-protein components, including the nucleotide GDP, F1ATP, and several nucleic acids.

CDC functions as a regulator of mitochondrial fusion by interacting with the protein Mitofusin, which is involved in the regulation of mitochondrial fusion and fission. CDC also functions as a regulator of cytoskeleton organization by interacting with several microtubule proteins, including tubulin, to maintain the integrity of the cytoskeleton during cell division and mechanical processes.

CDP and CDC as drug targets

The identification of CDC as a potential drug target has significant implications for the development of new therapeutic strategies for various diseases, including cancer, neurodegenerative disorders, and cardiovascular diseases.

CDP has been shown to play a role in the regulation of cellular processes that are relevant to several diseases, including cancer. For example, studies have shown that high levels of CDP are associated with poor prognosis in cancer patients. Additionally,CDP has been shown to be involved in the regulation of the angiogenic switch, which is the process by which cancer cells promote the formation of new blood vessels for the delivery of oxygen and nutrients.

CDC has also been shown to be involved in the regulation of mitochondrial physiology, which is critical for the production of energy by the cell through the

Protein Name: Cytoplasmic Dynein Complex

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